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Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.

Abstract:

Damaged DNA leads to genomic instability that causes many diseases such as cancer. Cells evolved the DNA damage response (DDR), which recognizes and efficiently repairs damaged DNA through the action of highly coordinated signalling mechanisms. Recently, a non-degradation-linked Lys(K)63-ubiquitin signal emerged as a signalling pathway essential for orchestration of the DDR after DNA double strand breaks (DSBs). How the ubiquitin-dependent proteasomal degradation system (UPS) coordinates DDR ...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
FEBS letters More from this journal
Volume:
585
Issue:
18
Pages:
2868-2875
Publication date:
2011-09-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:417371
UUID:
uuid:6c63b8b3-f542-4a35-a431-885aa1b91f0a
Local pid:
pubs:417371
Source identifiers:
417371
Deposit date:
2013-11-16

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