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Journal article

The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining.

Abstract:

Peptide-bound histocompatibility leukocyte antigen (HLA) class I tetramers enable a precise identification of antigen-specific CD8+ T cells using flow cytometry. The combination of this technology with intracellular staining techniques opens up significantly better ways of studying these cells than previously possible, allowing immunologists to look at their life cycle (activation and proliferation), manner of death (aging and apoptosis) and effector function (cytotoxic potential and cytokine...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of immunological methods
Volume:
268
Issue:
1
Pages:
9-19
Publication date:
2002-10-01
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
Source identifiers:
19403
Language:
English
Keywords:
Pubs id:
pubs:19403
UUID:
uuid:6c5d9743-12c0-4d69-b055-c9f6855df095
Local pid:
pubs:19403
Deposit date:
2012-12-19

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