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The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining.

Abstract:

Peptide-bound histocompatibility leukocyte antigen (HLA) class I tetramers enable a precise identification of antigen-specific CD8+ T cells using flow cytometry. The combination of this technology with intracellular staining techniques opens up significantly better ways of studying these cells than previously possible, allowing immunologists to look at their life cycle (activation and proliferation), manner of death (aging and apoptosis) and effector function (cytotoxic potential and cytokine...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Journal of immunological methods
Volume:
268
Issue:
1
Pages:
9-19
Publication date:
2002-10-05
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
URN:
uuid:6c5d9743-12c0-4d69-b055-c9f6855df095
Source identifiers:
19403
Local pid:
pubs:19403

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