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A GyrB-GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II.

Abstract:

BACKGROUND: Type II topoisomerases are a highly conserved class of enzymes which transport one double-stranded DNA segment through a transient break in another. Whereas the eukaryotic enzymes are homodimers of a single polypeptide, their bacterial homologues are homodimers of two independently coded protein subunits. Unlike eukaryotic topoisomerase II and bacterial topoisomerase IV, DNA gyrase is a bacterial type II topoisomerase which specializes in intramolecular DNA transport. RESULTS: We...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
Genes to cells : devoted to molecular and cellular mechanisms More from this journal
Volume:
7
Issue:
3
Pages:
249-257
Publication date:
2002-03-01
DOI:
EISSN:
1365-2443
ISSN:
1356-9597
Language:
English
Keywords:
Pubs id:
pubs:156022
UUID:
uuid:6c555065-c347-4a97-8315-f34768ac15cc
Local pid:
pubs:156022
Source identifiers:
156022
Deposit date:
2012-12-19

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