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High mutation rates in human and ape pseudoautosomal genes.

Abstract:

It has been suggested that recombination may be mutagenic, which, if true, would inflate intraspecies diversity and interspecies silent divergence in regions of high recombination. Here, we test this hypothesis comparing human/orangutan genome-wide non-coding divergence (K) to that in the pseudoautosomal genes which were reported to recombine much more frequently than the rest of the genome. We demonstrate that, compared to the average human/orangutan non-coding divergence (K=3%), the substit...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
Journal:
Gene
Volume:
317
Issue:
1-2
Pages:
67-77
Publication date:
2003-10-05
DOI:
EISSN:
1879-0038
ISSN:
0378-1119
URN:
uuid:6c53951f-4964-4161-81f7-fdcfd1adb66c
Source identifiers:
49204
Local pid:
pubs:49204

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