- Abstract:
-
DNA interstrand crosslinks (ICLs) are extremely cytotoxic, but the mechanism of their repair remains incompletely understood. Using Xenopus egg extracts, we previously showed that repair of a cisplatin ICL is triggered when two replication forks converge on the lesion. After CDC45/MCM2-7/GINS (CMG) ubiquitylation and unloading by the p97 segregase, FANCI-FANCD2 promotes DNA incisions by XPF-ERCC1, leading to ICL unhooking. Here, we report that, during this cell-free ICL repair reaction, one o...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 3.3mb)
-
(pdf, 7.2mb)
-
- Publisher copy:
- 10.1016/j.celrep.2018.05.061
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell reports Journal website
- Volume:
- 23
- Issue:
- 12
- Pages:
- 3419-3428
- Publication date:
- 2018-06-19
- Acceptance date:
- 2018-05-17
- DOI:
- EISSN:
-
2211-1247
- Pubs id:
-
pubs:858916
- URN:
-
uri:6c523452-eaef-42ec-b084-f3832ce2fa50
- UUID:
-
uuid:6c523452-eaef-42ec-b084-f3832ce2fa50
- Local pid:
- pubs:858916
- Language:
- English
- Keywords:
- Copyright holder:
- Amunugama et al.
- Copyright date:
- 2018
- Notes:
-
Copyright 2018 The Author(s). This is an open access article under
the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Journal article
Replication fork reversal during DNA interstrand crosslink repair requires CMG unloading
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