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Development of SimCells as a novel chassis for functional biosensors

Abstract:

This work serves as a proof-of-concept for bacterially derived SimCells (Simple Cells), which contain the cell machinery from bacteria and designed DNA (or potentially a simplified genome) to instruct the cell to carry out novel, specific tasks. SimCells represent a reprogrammable chassis without a native chromosome, which can host designed DNA to perform defined functions. In this paper, the use of Escherichia coli MC1000 ∆minD minicells as a non-reproducing chassis for SimCells was exp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-07391-6

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Institution:
University of Oxford
Division:
MPLS
Department:
Plant Sciences
Role:
Author
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Funding agency for:
Huang, W
Grant:
EP/M002403/1
EP/N009746/1
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Article number:
7261
Publication date:
2017-08-03
Acceptance date:
2017-06-28
DOI:
ISSN:
2045-2322
Source identifiers:
702104
Keywords:
Pubs id:
pubs:702104
UUID:
uuid:6c4cec15-c113-4643-9208-d0f36e79610f
Local pid:
pubs:702104
Deposit date:
2017-06-28

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