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Alternate dissociation pathways identified in charge-reduced protein complex ions.

Abstract:

Tandem mass spectrometry (MS) of large protein complexes has proven to be capable of assessing the stoichiometry, connectivity, and structural details of multiprotein assemblies. While the utility of tandem MS is without question, a deeper understanding of the mechanism of protein complex dissociation will undoubtedly drive the technology into new areas of enhanced utility and information content. We present here the systematic analysis of the charge state dependent decay of the noncovalently...

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Publication status:
Published

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Publisher copy:
10.1021/ac101121r
Journal:
Analytical chemistry More from this journal
Volume:
82
Issue:
12
Pages:
5363-5372
Publication date:
2010-06-01
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
Language:
English
Keywords:
Pubs id:
pubs:59341
UUID:
uuid:6c49a532-019c-43bb-973f-f3447251898c
Local pid:
pubs:59341
Source identifiers:
59341
Deposit date:
2012-12-19

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