Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene.

Journal article

Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was fo...

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Authors: Amin, M; Uhlig, H; Kamprad, M; Karbe, J; Osman, A

• Journal: Scandinavian journal of immunology
• Volume: 53
• Issue: 2
• Pages: 204-208
• Publication date: 2001-02-01
• DOI: 10.1046/j.1365-3083.2001.00839.x
• EISSN: 1365-3083
• ISSN: 0300-9475
• Language: English
• Keywords: Humans; Nuclear Proteins; Cerebellum; Nervous System Diseases; Muscle, Smooth; Autoimmune Diseases of the Nervous System; Autoantigens; Schwann Cells; Myelin Sheath; Intestine, Small; Brain Ischemia; Autoantibodies; Sequence Homology, Nucleic Acid; Nerve Tissue Proteins; Gene Library; Microscopy, Fluorescence; Intestinal Mucosa; Genes; Chromosomes, Human, Pair 4; Proteins; Immunoglobulin A