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Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene.

Abstract:

Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was fo...

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Journal:
Scandinavian journal of immunology More from this journal
Volume:
53
Issue:
2
Pages:
204-208
Publication date:
2001-02-01
DOI:
EISSN:
1365-3083
ISSN:
0300-9475

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