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NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF

Abstract:

While invasion and metastasis of tumour cells is the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to underpin alternative behaviors linked to tumour progression such as proliferation, survival and invasion. In the context of melanoma, heterogeneity between two transcription factors, BRN2 and MITF, have been associated with phenotypic switching betw...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ebiom.2017.01.013

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Publisher:
Elsevier
Journal:
EBioMedicine More from this journal
Volume:
16
Pages:
63-75
Publication date:
2017-01-16
Acceptance date:
2017-01-09
DOI:
ISSN:
2352-3964
Keywords:
Pubs id:
pubs:671464
UUID:
uuid:6c3442f3-1ce2-4376-b8d6-0bdfa7a14a1a
Local pid:
pubs:671464
Source identifiers:
671464
Deposit date:
2017-01-17

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