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Effect of pretransplant preconditioning by whole body hyperthermia on islet graft survival.

Abstract:

Previous observations in heat-shocked pig islets revealed the ambivalent character of the stress response simultaneously inducing processes of protection and apoptosis. To clarify whether the proapoptotic character of the stress response is reduced in heat-exposed islets still embedded in their native environment, hyperthermia was performed in the present study either as whole body hyperthermia (WBH) prior to pancreas resection or as in vitro heat shock (HS) after isolation. HS (42 degrees C/...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Cell transplantation
Volume:
16
Issue:
7
Pages:
707-715
Publication date:
2007-01-01
EISSN:
1555-3892
ISSN:
0963-6897
URN:
uuid:6c2fd00c-1b16-4f9c-8690-71d5a5883744
Source identifiers:
261506
Local pid:
pubs:261506

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