Control of the expression of inflammatory response genes.

Journal article

The expression of genes involved in the inflammatory response is controlled both transcriptionally and post-transcriptionally. Primary inflammatory stimuli, such as microbial products and the cytokines interleukin-1 (IL-1) and tumour necrosis factor alpha (TNF alpha), act through receptors of either the Toll and IL-1 receptor (TIR) family or the TNF receptor family. These cause changes in gene expression by activating four major intracellular signalling pathways that are cascades of protein k...

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Authors: Saklatvala, J; Dean, J; Clark, A

• Publication status: Published
• Journal: Biochemical Society symposium
• Volume: 70
• Issue: 70
• Pages: 95-106
• Publication date: 2003-01-01
• DOI: 10.1042/bss0700095
• EISSN: 1744-1439
• ISSN: 0067-8694
• Language: English
• Keywords: Inflammation Mediators; Animals; Transcription, Genetic; Inflammation; Gene Expression Regulation; Matrix Metalloproteinases; Signal Transduction; Glucocorticoids; RNA Processing, Post-Transcriptional; RNA, Messenger