- Subtitle:
- Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?
- Abstract:
-
Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in SE Asian malaria parasite (Plasmodium falciparum) populations under artemisinin selection over the past 15 years in a dramatic example of a soft selective event. However, just one of these alleles (C580Y) is now outcompeting other alleles in multiple different co...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.2mb)
-
- Publisher copy:
- 10.1128/aac.00605-18
-
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- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 62
- Issue:
- 9
- Publication date:
- 2018-06-18
- Acceptance date:
- 2018-06-13
- DOI:
- EISSN:
-
1098-6596
- ISSN:
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0066-4804
- Pubs id:
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pubs:859563
- URN:
-
uri:6c2d5793-1e4f-4145-95f4-275ef6abdb2f
- UUID:
-
uuid:6c2d5793-1e4f-4145-95f4-275ef6abdb2f
- Local pid:
- pubs:859563
- Language:
- English
- Keywords:
- Copyright holder:
- Nair et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Nair et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Journal article
Fitness costs and the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance
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