Fitness costs and the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance
- Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?
Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in SE Asian malaria parasite (Plasmodium falciparum) populations under artemisinin selection over the past 15 years in a dramatic example of a soft selective event. However, just one of these alleles (C580Y) is now outcompeting other alleles in multiple different co...Expand abstract
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Copyright © 2018 Nair et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.