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Journal article

Fitness costs and the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance

Subtitle:
Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?
Abstract:

Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in SE Asian malaria parasite (Plasmodium falciparum) populations under artemisinin selection over the past 15 years in a dramatic example of a soft selective event. However, just one of these alleles (C580Y) is now outcompeting other alleles in multiple different co...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1128/aac.00605-18

Authors


McDew-white, M More by this author
Ferrari, M More by this author
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Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
9
Publication date:
2018-06-18
Acceptance date:
2018-06-13
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:859563
URN:
uri:6c2d5793-1e4f-4145-95f4-275ef6abdb2f
UUID:
uuid:6c2d5793-1e4f-4145-95f4-275ef6abdb2f
Local pid:
pubs:859563

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