Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol.

Journal article

We report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal resid...

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Authors: Patrick, K; Wade, R; Goulden, N; Rowntree, C; Hough, R

• Publication status: Published
• Journal: British journal of haematology
• Volume: 165
• Issue: 4
• Pages: 552-555
• Publication date: 2014-05-01
• DOI: 10.1111/bjh.12739
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Disease-Free Survival; Recurrence; Treatment Outcome; Infection; Gastrointestinal Hemorrhage; Young Adult; Child; Child, Preschool; Follow-Up Studies; Humans; Female; Neoplasm, Residual; Adolescent; Down Syndrome; Genetic Predisposition to Disease; Risk Assessment; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Male; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Infant