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Molecular architecture and ligand recognition determinants for T4 RNA ligase.

Abstract:

RNA ligase type 1 from bacteriophage T4 (Rnl1) is involved in countering a host defense mechanism by repairing 5'-PO4 and 3'-OH groups in tRNA(Lys). Rnl1 is widely used as a reagent in molecular biology. Although many structures for DNA ligases are available, only fragments of RNA ligases such as Rnl2 are known. We report the first crystal structure of a complete RNA ligase, Rnl1, in complex with adenosine 5'-(alpha,beta-methylenetriphosphate) (AMPcPP). The N-terminal domain is related to the...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m509658200

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Journal:
The Journal of biological chemistry
Volume:
281
Issue:
3
Pages:
1573-1579
Publication date:
2006-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:6c20cd89-270c-4e9e-91fe-db5e7b467695
Source identifiers:
72628
Local pid:
pubs:72628

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