Journal article icon

Journal article

Evaluating safety reporting in paediatric antibiotic trials 2000-2016: a systematic review and meta-analysis

Abstract:

Importance: There are very few options to treat multidrug resistant bacterial infections in children. A major barrier is the duration and complexity of regulatory trials of new antibiotics. Extrapolation of safety data from adult trials could facilitate drug development for children.

Objective: We performed a systematic review on safety of antibiotic clinical trials (CTs) in children (0-18 years) to evaluate the overall quality of safety trials conducted in children and to determine...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1007/s40265-017-0850-x

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Springer Verlag
Journal:
Drugs More from this journal
Volume:
78
Issue:
2
Pages:
231-244
Publication date:
2017-12-07
Acceptance date:
2017-11-21
DOI:
EISSN:
1179-1950
ISSN:
0012-6667
Pubs id:
pubs:747099
UUID:
uuid:6c1f6b4a-933a-4ad2-9bc8-93685831f695
Local pid:
pubs:747099
Source identifiers:
747099
Deposit date:
2017-11-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP