Journal article
Evaluating safety reporting in paediatric antibiotic trials 2000-2016: a systematic review and meta-analysis
- Abstract:
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Importance: There are very few options to treat multidrug resistant bacterial infections in children. A major barrier is the duration and complexity of regulatory trials of new antibiotics. Extrapolation of safety data from adult trials could facilitate drug development for children.
Objective: We performed a systematic review on safety of antibiotic clinical trials (CTs) in children (0-18 years) to evaluate the overall quality of safety trials conducted in children and to determine...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, x-zip-compressed, 740.2KB, Terms of use)
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- Publisher copy:
- 10.1007/s40265-017-0850-x
Authors
- Publisher:
- Springer Verlag
- Journal:
- Drugs More from this journal
- Volume:
- 78
- Issue:
- 2
- Pages:
- 231-244
- Publication date:
- 2017-12-07
- Acceptance date:
- 2017-11-21
- DOI:
- EISSN:
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1179-1950
- ISSN:
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0012-6667
- Pubs id:
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pubs:747099
- UUID:
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uuid:6c1f6b4a-933a-4ad2-9bc8-93685831f695
- Local pid:
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pubs:747099
- Source identifiers:
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747099
- Deposit date:
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2017-11-21
Terms of use
- Copyright holder:
- Springer International Publishing AG
- Copyright date:
- 2017
- Notes:
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© Springer International Publishing AG, part of Springer Nature 2017. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at:
10.1007/s40265-017-0850-x
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