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Journal article

Cerebral calpain in fatal falciparum malaria.

Abstract:

Disruption of axonal transport may represent a final common pathway leading to neurological dysfunction in cerebral malaria (CM). Calpains are calcium (Ca2+)-activated cysteine proteases which have been implicated in axonal injury in neurological diseases of various aetiologies. In this study we examined the association between mu- and m-calpain, the specific inhibitor calpastatin, and axonal injury in post mortem brain tissue from patients who died from severe malaria. Calpains were associat...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Neuropathology and applied neurobiology More from this journal
Volume:
33
Issue:
2
Pages:
179-192
Publication date:
2007-04-01
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
Language:
English
Keywords:
Pubs id:
pubs:20828
UUID:
uuid:6c1df414-b1b2-44dc-8941-e9e9da9a561b
Local pid:
pubs:20828
Source identifiers:
20828
Deposit date:
2012-12-19

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