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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.

Abstract:

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.We applied Mendelian randomization to evaluate the association between BMI and risk of breast cancer occurrence using data from two large breast cancer consortia. We created a weighted BMI genetic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
  • (Version of record, pdf, 850.0KB)
Publisher copy:
10.1371/journal.pmed.1002105

Authors


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Name:
National Cancer Institute
Grant:
R25CA160056
R37CA070867
Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Issue:
8
Publication date:
2016-08-23
Acceptance date:
2016-06-24
DOI:
ISSN:
1549-1277 and 1549-1676
Pmid:
27551723
Language:
English
Keywords:
Pubs id:
pubs:640490
UUID:
uuid:6c16eb19-73da-4fb3-acb0-519402de4d1b
Local pid:
pubs:640490
Source identifiers:
640490
Deposit date:
2016-09-16

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