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A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.

Abstract:

The sulphonylurea receptor (SUR1) subunit of the ATP-sensitive potassium (KATP) channel is a member of the ATP-binding cassette (ABC) protein family. Binding of MgADP to nucleotide-binding domain 2 (NBD2) is critical for channel activation.We identified a residue in NBD2 (G1401) that is fully conserved among ABC proteins and whose functional importance is unknown. Homology modelling places G1401 on the outer surface of the protein, distant from the nucleotide-binding site. The ATPase activity...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Shimomura, K More by this author
Aittoniemi, J More by this author
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Journal:
The Journal of physiology
Volume:
590
Issue:
Pt 20
Pages:
5025-5036
Publication date:
2012-10-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:6c0dc40a-03a2-4509-bede-c7f2c09bdab6
Source identifiers:
342334
Local pid:
pubs:342334

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