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Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.

Abstract:

In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon (IFN)-gamma-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related...

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Publication status:
Published

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Publisher copy:
10.1038/nm881

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Journal:
Nature medicine
Volume:
9
Issue:
6
Pages:
729-735
Publication date:
2003-06-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Source identifiers:
23968

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