- Abstract:
-
In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon (IFN)-gamma-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related...
Expand abstract - Publication status:
- Published
- Journal:
- Nature medicine
- Volume:
- 9
- Issue:
- 6
- Pages:
- 729-735
- Publication date:
- 2003-06-05
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- URN:
-
uuid:6c059980-68ea-4bd8-8583-6a1b0ebce39c
- Source identifiers:
-
23968
- Local pid:
- pubs:23968
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.
Actions
Authors
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record