- Abstract:
-
In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon (IFN)-gamma-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nm881
-
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- Journal:
- Nature medicine
- Volume:
- 9
- Issue:
- 6
- Pages:
- 729-735
- Publication date:
- 2003-06-05
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- URN:
-
uuid:6c059980-68ea-4bd8-8583-6a1b0ebce39c
- Source identifiers:
-
23968
- Local pid:
- pubs:23968
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.
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