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Journal article

The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release.

Abstract:

This study aimed to investigate whether the growth hormone release and metabolic effects of ghrelin on AMPK activity of peripheral tissues are mediated by cannabinoid receptor type 1 (CB1) and the central nervous system. CB1-knockout (KO) and/or wild-type mice were injected peripherally or intracerebroventricularly with ghrelin and CB1 antagonist rimonabant to study tissue AMPK activity and gene expression (transcription factors SREBP1c, transmembrane protein FAS, enzyme PEPCK, and protein HS...

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Publication status:
Published

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Publisher copy:
10.1096/fj.13-232918

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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
27
Issue:
12
Pages:
5112-5121
Publication date:
2013-12-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Source identifiers:
421110
Language:
English
Keywords:
Pubs id:
pubs:421110
UUID:
uuid:6c0475ce-9337-4643-9f40-4351d97b04cd
Local pid:
pubs:421110
Deposit date:
2013-11-16

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