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Journal article

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding.

Abstract:

ATP-sensitive potassium (K(ATP)) channels are composed of an ATP-binding cassette (ABC) protein (SUR1, SUR2A or SUR2B) and an inwardly rectifying K(+) channel (Kir6.1 or Kir6.2). Like other ABC proteins, the nucleotide binding domains (NBDs) of SUR contain a highly conserved "signature sequence" (the linker, LSGGQ) whose function is unclear. Mutation of the conserved serine to arginine in the linker of NBD1 (S1R) or NBD2 (S2R) did not alter the ability of ATP or ADP (100 microM) to displace 8...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/cdf419

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
EMBO journal More from this journal
Volume:
21
Issue:
16
Pages:
4250-4258
Publication date:
2002-08-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189

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