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Genetic association analysis of LARS2 with type 2 diabetes.

Abstract:

AIMS/HYPOTHESIS: LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). However, this association did not achieve genome-wide levels of significance. The aim of this study was to establish the true contribution of this variant and common variants in LARS2 (MAF > 5%) to type 2 diabetes risk. METHODS: We combined genome-wide association data (n = 10,128) from the DIAGRA...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-009-1557-7

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Journal:
Diabetologia
Volume:
53
Issue:
1
Pages:
103-110
Publication date:
2010-01-01
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Source identifiers:
10241

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