- Abstract:
-
A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RB(high)CD4(+) T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RB(low) subset. Analysis of the mechanism of immune suppression transferred by CD45RB(low)CD4(+) cells revealed essential roles for both IL-10 and TGF-beta. These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in ...
Expand abstract - Publisher copy:
- 10.1164/ajrccm.162.supplement_3.15tac9
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- Journal:
- American journal of respiratory and critical care medicine
- Volume:
- 162
- Issue:
- 4 Pt 2
- Pages:
- S185-S189
- Publication date:
- 2000-10-05
- DOI:
- EISSN:
-
1535-4970
- ISSN:
-
1073-449X
- URN:
-
uuid:6bfa4904-6bae-4640-be45-bed709d8d659
- Source identifiers:
-
12907
- Local pid:
- pubs:12907
- Copyright date:
- 2000
Journal article
Control of experimental inflammatory bowel disease by regulatory T cells.
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