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Journal article

Control of experimental inflammatory bowel disease by regulatory T cells.

Abstract:

A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RB(high)CD4(+) T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RB(low) subset. Analysis of the mechanism of immune suppression transferred by CD45RB(low)CD4(+) cells revealed essential roles for both IL-10 and TGF-beta. These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in ...

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Journal:
American journal of respiratory and critical care medicine
Volume:
162
Issue:
4 Pt 2
Pages:
S185-S189
Publication date:
2000-10-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:6bfa4904-6bae-4640-be45-bed709d8d659
Source identifiers:
12907
Local pid:
pubs:12907

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