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Thesis

Developing viral vectored vaccines for MAGE-expressing tumours

Abstract:

The MAGE-type antigen family represent excellent targets for a therapeutic cancer vaccine. However, numerous attempts to develop effective MAGE-targeting cancer vaccines to date have shown poor induction of specific CD8+ T-cell responses and little clinical efficacy. In this study, a novel vaccination strategy based on a heterologous prime-boost with recombinant Chimpanzee Adenovirus (ChAdOx1) and Modified vaccinia Ankara (MVA) viral vectors was assessed for its potential in targeting MAGE-ex...

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Division:
MSD
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Author

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Supervisor
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Supervisor
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Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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Deposit date:
2022-03-25

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