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Journal article

Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.

Abstract:

The c-Fes protein-tyrosine kinase modulates cellular signaling pathways governing differentiation, the innate immune response, and vasculogenesis. Here, we report the identification of types I and II kinase inhibitors with potent activity against c-Fes both in vitro and in cell-based assays. One of the most potent inhibitors is the previously described anaplastic lymphoma kinase inhibitor TAE684. The crystal structure of TAE684 in complex with the c-Fes SH2-kinase domain showed excellent shap...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Chemistry and biology More from this journal
Volume:
19
Issue:
4
Pages:
529-540
Publication date:
2012-04-01
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
Language:
English
Keywords:
Pubs id:
pubs:325529
UUID:
uuid:6be8b5ee-d0b4-4a67-8477-1589fd0f2dbd
Local pid:
pubs:325529
Source identifiers:
325529
Deposit date:
2012-12-19

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