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Journal article

Prioritizing natural product diversity in a collection of 146 bacterial strains based on growth and extraction protocols

Abstract:

In order to expedite the rapid and efficient discovery and isolation of novel specialized metabolites, whilst minimizing the waste of resources on rediscovery of known compounds, it is crucial to develop efficient approaches for strain prioritization, rapid dereplication, and the assessment of favored cultivation and extraction conditions. Herein we interrogated bacterial strains by systematically evaluating cultivation and extraction parameters with LC-MS/MS analysis and subsequent dereplica...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jnatprod.6b00722

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Plant Sciences
Role:
Author
More from this funder
Name:
Deutsche Forschungsgemeinschaft
Grant:
CR 464-1 to M.C
More from this funder
Name:
São Paulo Research Foundation
Grant:
FAPESP 2015/03348-3 to R.R.d.S
More from this funder
Name:
National Institutes of Health
Grant:
R.01-GM085770toB.S.M.
R01-GM097509toB.S.M
P.R.J
P.C.D
Publisher:
American Chemical Society
Journal:
Journal of Natural Products More from this journal
Volume:
80
Issue:
3
Pages:
588–597
Publication date:
2016-01-01
Acceptance date:
2016-11-04
DOI:
EISSN:
1520-6025
ISSN:
0163-3864
Pubs id:
pubs:657372
UUID:
uuid:6bd8c92d-f9af-4e66-85d8-44563dd2f02d
Local pid:
pubs:657372
Source identifiers:
657372
Deposit date:
2016-11-07

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