Journal article
Prioritizing natural product diversity in a collection of 146 bacterial strains based on growth and extraction protocols
- Abstract:
-
In order to expedite the rapid and efficient discovery and isolation of novel specialized metabolites, whilst minimizing the waste of resources on rediscovery of known compounds, it is crucial to develop efficient approaches for strain prioritization, rapid dereplication, and the assessment of favored cultivation and extraction conditions. Herein we interrogated bacterial strains by systematically evaluating cultivation and extraction parameters with LC-MS/MS analysis and subsequent dereplica...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Accepted manuscript, pdf, 7.6MB)
-
- Publisher copy:
- 10.1021/acs.jnatprod.6b00722
Authors
Funding
+ National Institutes of Health
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Grant:
R.01-GM085770toB.S.M.
R01-GM097509toB.S.M
P.R.J
P.C.D
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Natural Products Journal website
- Volume:
- 80
- Issue:
- 3
- Pages:
- 588–597
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-11-04
- DOI:
- EISSN:
-
1520-6025
- ISSN:
-
0163-3864
Item Description
- Pubs id:
-
pubs:657372
- UUID:
-
uuid:6bd8c92d-f9af-4e66-85d8-44563dd2f02d
- Local pid:
- pubs:657372
- Source identifiers:
-
657372
- Deposit date:
- 2016-11-07
Terms of use
- Copyright holder:
- The American Chemical Society and American Society of Pharmacognosy
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The American Chemical Society and American Society of Pharmacognosy. This is the accepted manuscript version of the article. The final version is available online from the American Chemical Society at: https://doi.org/10.1021/acs.jnatprod.6b00722
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