We study the constraints on five-dimensional script N = 1 heterotic M-theory imposed by a consistent anomaly-free coupling of bulk and boundary theory. This requires analyzing the cancellation of triangle gauge anomalies on the four-dimensional orbifold planes due to anomaly inflow from the bulk. We find that the semi-simple part of the orbifold gauge groups and certain U(1) symmetries have to be free of quantum anomalies. In addition there can be several anomalous U(1) symmetries on each orb...