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Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.

Abstract:

The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development, tumour suppression and signalling. The ligand IGF2 is implicated in the growth phenotype, where IGF2R normally limits bioavailability, such that loss and gain of IGF2R results in increased and re...

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Publication status:
Published

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Publisher copy:
10.1677/jme-08-0154

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Journal:
Journal of molecular endocrinology More from this journal
Volume:
42
Issue:
4
Pages:
341-356
Publication date:
2009-04-01
DOI:
EISSN:
1479-6813
ISSN:
0952-5041

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