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VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors.

Abstract:

The spread of cancer cells to regional lymph nodes through the lymphatic system is the first step in the dissemination of breast cancer. In several human cancers including those of the breast and prostate, the expression of vascular endothelial growth factor C (VEGF-C) is associated with lymph node metastasis. Our study was undertaken to evaluate the effect of VEGF-C on metastasis of poorly invasive, estrogen dependent human MCF-7 breast cancer cells. MCF-7 breast cancer cells transfected wit...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.10283

Authors


Mattila, MM More by this author
Ruohola, JK More by this author
Karpanen, T More by this author
Jackson, DG More by this author
Alitalo, K More by this author
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Journal:
International journal of cancer. Journal international du cancer
Volume:
98
Issue:
6
Pages:
946-951
Publication date:
2002-04-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:6bd581d1-3643-4de0-bc50-6c0ac8e3ead4
Source identifiers:
102757
Local pid:
pubs:102757

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