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Role of Syk in B-cell development and antigen-receptor signaling.

Abstract:

Antigen receptors (BCRs) on developing B lymphocytes play two opposing roles-promoting survival of cells that may later bind a foreign antigen and inhibiting survival of cells that bind too strongly to self-antigens. It is not known how these opposing outcomes are signaled by BCRs on immature B cells. Here we analyze the effect of a null mutation in the Syk tyrosine kinase on maturing B cells displaying a transgene-encoded BCR that binds hen egg lysozyme (HEL). In the absence of HEL antigen, ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.97.4.1713

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
4
Pages:
1713-1718
Publication date:
2000-02-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
20714

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