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Role of Syk in B-cell development and antigen-receptor signaling.

Abstract:

Antigen receptors (BCRs) on developing B lymphocytes play two opposing roles-promoting survival of cells that may later bind a foreign antigen and inhibiting survival of cells that bind too strongly to self-antigens. It is not known how these opposing outcomes are signaled by BCRs on immature B cells. Here we analyze the effect of a null mutation in the Syk tyrosine kinase on maturing B cells displaying a transgene-encoded BCR that binds hen egg lysozyme (HEL). In the absence of HEL antigen, ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.97.4.1713

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Molecular Medicine
Goodnow, CC More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
4
Pages:
1713-1718
Publication date:
2000-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:6bcae6bd-8a3b-4e10-b19f-5f097d50d24d
Source identifiers:
20714
Local pid:
pubs:20714

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