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Tension induces a base-paired overstretched DNA conformation.

Abstract:

Mixed-sequence DNA molecules undergo mechanical overstretching by approximately 70% at 60-70 pN. Since its initial discovery 15 y ago, a debate has arisen as to whether the molecule adopts a new form [Cluzel P, et al. (1996) Science 271:792-794; Smith SB, Cui Y, Bustamante C (1996) Science 271:795-799], or simply denatures under tension [van Mameren J, et al. (2009) Proc Natl Acad Sci USA 106:18231-18236]. Here, we resolve this controversy by using optical tweezers to extend small 60-64 bp si...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1213172109

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
38
Pages:
15179-15184
Publication date:
2012-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:6bc9c379-1a53-432d-9f69-4d20d214c5c4
Source identifiers:
400114
Local pid:
pubs:400114

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