Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc.
The present numerical study aims to investigate the disc nutrition and factors affecting it by evaluating the concentrations of oxygen, glucose and lactic acid in the disc while accounting for the coupling between these species via the pH level in the tissue and the nonlinear concentration-consumption (for glucose and oxygen) and concentration-production (for lactate) relations. The effects of changes in the endplate exchange area (EA) adjacent to the nucleus or the inner annulus for the tran...Expand abstract
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