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Fixed duration interruptions are inferior to continuous treatment in African adults starting therapy with CD4 cell counts < 200 cells/microl.

Abstract:

BACKGROUND: Structured treatment interruption (STI) of antiretroviral therapy (ART) could potentially reduce cost and toxicity, but clinical efficacy requires evaluation. METHODS: An assessment of fixed-duration STI was nested in DART, a multicentre trial comparing strategies for monitoring ART in Uganda and Zimbabwe (ISCRTN 13968779). Of 3316 ART-naive symptomatic adults with CD4 cell count < 200 cells/microl at ART initiation, 813 with > or = 300 cells/microl after 48 or 72 weeks unde...

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Publication status:
Published

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Journal:
AIDS (London, England) More from this journal
Volume:
22
Issue:
2
Pages:
237-247
Publication date:
2008-01-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370

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