Fixed duration interruptions are inferior to continuous treatment in African adults starting therapy with CD4 cell counts < 200 cells/microl.

Journal article

BACKGROUND: Structured treatment interruption (STI) of antiretroviral therapy (ART) could potentially reduce cost and toxicity, but clinical efficacy requires evaluation. METHODS: An assessment of fixed-duration STI was nested in DART, a multicentre trial comparing strategies for monitoring ART in Uganda and Zimbabwe (ISCRTN 13968779). Of 3316 ART-naive symptomatic adults with CD4 cell count < 200 cells/microl at ART initiation, 813 with > or = 300 cells/microl after 48 or 72 weeks unde...

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Authors: DART Trial Team

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 22
• Issue: 2
• Pages: 237-247
• Publication date: 2008-01-01
• DOI: 10.1097/qad.0b013e3282f2d760
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: Zidovudine; Uganda; Female; CD4 Lymphocyte Count; AIDS-Related Opportunistic Infections; Adult; Middle Aged; Anti-HIV Agents; Male; Candidiasis; Acquired Immunodeficiency Syndrome; Treatment Outcome; Drug Administration Schedule; Disease Progression; Esophageal Diseases; Antiretroviral Therapy, Highly Active; Humans; HIV; DART Trial Team; Zimbabwe; Anti-Retroviral Agents; Aged