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Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells.

Abstract:

It has been proposed that endogenous H(2)S mediates oxygen sensing in chemoreceptors; this study investigates the mechanisms by which H(2)S excites carotid body type 1 cells. H(2)S caused a rapid reversible increase in intracellular calcium with EC(50) ≈ 6 μM. This [Ca(2+)](i) response was abolished in Ca-free Tyrode. In perforated patch current clamp recordings, H(2)S depolarised type 1 cells from -59 to -35 mV; this was accompanied by a robust increase in [Ca(2+)](i). Voltage clamping at th...

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Publication status:
Published

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Publisher copy:
10.1007/s00424-012-1089-8

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology
Volume:
463
Issue:
5
Pages:
743-754
Publication date:
2012-04-01
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
Source identifiers:
316379

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