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Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

Abstract:

The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. We identified GLIS3 binding sites in insulin secreting cells (INS1) (FDR q<0.05; enrichment range 1.40-9.11 fold) sharing the motif wrGTTCCCArTAGs, which were enriched in genes involved in neuronal function and autophagy and in risk genes for metabolic and neuro-behavioural diseases. We confirmed experimentally Glis3-mediated regulation of the express...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ygeno.2017.09.001

Authors


Calderari, S More by this author
Gérard, C More by this author
Nogueira, TC More by this author
Villate, O More by this author
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Grant:
Seventh Framework Programme (FP7/2007-2013) under grant agreements N° HEALTH-F4-2010-241504 (EURATRANS) to DG and N° HEALTH-F2-2011-277713 (BetaBat) to DLE and MC
Publisher:
Elsevier Publisher's website
Journal:
Genomics Journal website
Volume:
110
Issue:
2
Pages:
98-111
Publication date:
2018-09-11
Acceptance date:
2018-09-01
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
Pubs id:
pubs:729976
URN:
uri:6bb1078e-92cd-4f11-bc8b-2ac16946bfd7
UUID:
uuid:6bb1078e-92cd-4f11-bc8b-2ac16946bfd7
Local pid:
pubs:729976

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