- Abstract:
-
The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. We identified GLIS3 binding sites in insulin secreting cells (INS1) (FDR q<0.05; enrichment range 1.40-9.11 fold) sharing the motif wrGTTCCCArTAGs, which were enriched in genes involved in neuronal function and autophagy and in risk genes for metabolic and neuro-behavioural diseases. We confirmed experimentally Glis3-mediated regulation of the express...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 326.8kb)
-
(pptx, 7.4mb)
-
- Publisher copy:
- 10.1016/j.ygeno.2017.09.001
-
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- Grant:
- Seventh Framework Programme (FP7/2007-2013) under grant agreements N° HEALTH-F4-2010-241504 (EURATRANS) to DG and N° HEALTH-F2-2011-277713 (BetaBat) to DLE and MC
- Publisher:
- Elsevier Publisher's website
- Journal:
- Genomics Journal website
- Volume:
- 110
- Issue:
- 2
- Pages:
- 98-111
- Publication date:
- 2018-09-11
- Acceptance date:
- 2018-09-01
- DOI:
- EISSN:
-
1089-8646
- ISSN:
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0888-7543
- Pubs id:
-
pubs:729976
- URN:
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uri:6bb1078e-92cd-4f11-bc8b-2ac16946bfd7
- UUID:
-
uuid:6bb1078e-92cd-4f11-bc8b-2ac16946bfd7
- Local pid:
- pubs:729976
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2017 Elsevier Inc. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.ygeno.2017.09.001
Journal article
Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons
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