Redox sensor and effector functions of tetrahydrobiopterin and the mitochondria in molecular models of cardiovascular disease

Thesis

Tetrahydrobiopterin (BH₄) is a redox active molecule that is essential for the production of nitric oxide (NO) by the NO synthase (NOS) enzymes. Loss of endothelial BH₄ leads to decreased NO and increased superoxide generation by endothelial NOS (eNOS) uncoupling, and the resulting endothelial dysfunction is involved in the pathogenesis of vascular diseases. Although genetic augmentation of endothelial BH₄ synthesis has proven successful at normalising dysf...

Expand abstract

Authors: Bailey, J

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Mitochondria; Metabolism; Macrophages; Redox; Tetrahydrobiopterin; Immunometabolism; Endotheliall cells; Nitric oxide
• Subjects: Mitochondria; Metabolism; Redox signalling; Cardiovascular system--Diseases; Immunometabolism