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Thesis

Redox sensor and effector functions of tetrahydrobiopterin and the mitochondria in molecular models of cardiovascular disease

Abstract:

Tetrahydrobiopterin (BH4) is a redox active molecule that is essential for the production of nitric oxide (NO) by the NO synthase (NOS) enzymes. Loss of endothelial BH4 leads to decreased NO and increased superoxide generation by endothelial NOS (eNOS) uncoupling, and the resulting endothelial dysfunction is involved in the pathogenesis of vascular diseases. Although genetic augmentation of endothelial BH4 synthesis has proven successful at normalising dysf...

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
More from this funder
Name:
British Heart Foundation
Funding agency for:
Bailey, J
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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