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Residue-selective protein C-formylation via sequential difluoroalkylation-hydrolysis

Abstract:

The carbonyl group is now a widely useful, nonproteinogenic functional group in chemical biology, yet methods for its generation in proteins have relied upon either cotranslational incorporation of unnatural amino acids bearing carbonyls or oxidative conversion (chemical or enzymatic) of existing natural amino acids. If available, alternative strategies for directly adding the C=O group through C-C bond-forming C-carbonylation, particularly at currently inaccessible amino acid sites, would pr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acscentsci.0c01193

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0001-8638-5308
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Publisher:
American Chemical Society Publisher's website
Journal:
ACS Central Science Journal website
Volume:
7
Issue:
1
Pages:
145-155
Publication date:
2021-01-13
Acceptance date:
2021-01-13
DOI:
EISSN:
2374-7951
ISSN:
2374-7943
Pmid:
33532577
Language:
English
Keywords:
Pubs id:
1162898
Local pid:
pubs:1162898
Deposit date:
2021-06-24

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