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Journal article

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen.

Abstract:

Although the accelerated atherosclerosis and premature aging of the cardiovascular system in patients with metabolic syndrome have been appreciated, the mechanisms of their development and potential therapeutic interventions remain unresolved. Our previous studies implicated advanced glycosylation end products in development of premature senescence preventable with a peroxynitrite scavenger, ebselen. Therefore, the effect of ebselen on endothelial senescence and vasculopathy in a model of met...

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Publication status:
Published

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Journal:
Circulation research
Volume:
94
Issue:
3
Pages:
377-384
Publication date:
2004-02-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Source identifiers:
342147

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