Cytokine blockade in rheumatoid arthritis.

Feldmann, M; Maini, RN; Bondeson, J; Taylor, P; Foxwell, BM; Brennan, FM

Abstract:

As we enter the 2000's it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFalpha therapy, the current status of therapy and focus on the regulation of TNFalpha production in rheumatoid synovium. New approaches to studying TNF regulation in RA and of elucidating the controversial role of T cells in this complex disease will be described.

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Published

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APA Style

Feldmann, M., Maini, R. N., Bondeson, J., Taylor, P., Foxwell, B. M., & Brennan, F. M. (2001). Cytokine blockade in rheumatoid arthritis. Advances in Experimental Medicine and Biology, 490, 119–127.

MLA Style

Feldmann, M., et al. “Cytokine Blockade in Rheumatoid Arthritis.” Advances in Experimental Medicine and Biology, vol. 490, Advances in experimental medicine and biology, 2001, pp. 119–27.

Chicago Style

Feldmann, M, RN Maini, J Bondeson, P Taylor, BM Foxwell, and FM Brennan. 2001. “Cytokine Blockade in Rheumatoid Arthritis.” Advances in Experimental Medicine and Biology 490: 119–27.
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+ Feldmann, M More by this author

Institution:

University of Oxford

Department:

Oxford, MSD, NDORMS

Maini, RN More by this author

Bondeson, J More by this author

Taylor, P More by this author

Foxwell, BM More by this author

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Bibliographic Details

Journal:: Advances in experimental medicine and biology
Volume:: 490
Pages:: 119-127
Publication date:: 2001
ISSN:: 0065-2598
URN:: uuid:6b9acc0e-ef94-4760-b8b2-66d5488c32c0
Source identifiers:: 224464
Local pid:: pubs:224464

Item Description

Language:: English
Keywords:: Arthritis, Rheumatoid

Tumor Necrosis Factor-alpha

T-Lymphocytes

I-kappa B Proteins

Humans

Interleukin-1

NF-kappa B

Adenoviridae

DNA-Binding Proteins

Cytokines

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