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Journal article

Broad HIV-1 inhibition in vitro by vaccine-elicited CD8+ T cells in African adults

Abstract:

We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally conserved regions (not full-length proteins and not only epitopes) of the HIV-1 proteome, which are common to most global variants and which, if mutated, cause a replicative fitness loss. Our first clinical trial in low risk HIV-1-negative adults in Oxford demonstrated ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mtm.2016.61

Authors


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International AIDS Vaccine Initiative More from this funder
Swedish International Development Cooperation Agency More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Therapy - Methods and Clinical Development Journal website
Volume:
3
Article number:
16061
Publication date:
2017-02-20
Acceptance date:
2016-07-22
DOI:
ISSN:
2329-0501
Pmid:
27617268
Source identifiers:
644034
Language:
English
Pubs id:
pubs:644034
UUID:
uuid:6b9052a3-1243-4540-bc75-18af05f85a1c
Local pid:
pubs:644034
Deposit date:
2018-07-24

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