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Memory T cell inflation: Understanding cause and effect

Abstract:

Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discu...

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Publisher copy:
10.1016/j.it.2011.11.005

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Trends in Immunology
Volume:
33
Issue:
2
Pages:
84-90
Publication date:
2012-02-01
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
Source identifiers:
313884
Language:
English
Keywords:
Pubs id:
pubs:313884
UUID:
uuid:6b8cc367-0c2c-417c-8ae7-fb6a570fda26
Local pid:
pubs:313884
Deposit date:
2012-12-19

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