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Bioprocess decision support tool for scalable manufacture of extracellular vesicles

Abstract:

Newly recognized as natural nanocarriers that deliver biological information between cells, extracellular vesicles (EVs), including exosomes and microvesicles, provide unprecedented therapeutic opportunities. Large‐scale and cost‐effective manufacturing is imperative for EV products to meet commercial and clinical demands; successful translation requires careful decisions that minimize financial and technological risks. Here, we develop a decision support tool (DST) that computes the most cos...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bit.26809

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0003-2634-0268
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Name:
Medical Research Council
Grant:
J.A.S.
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Name:
Agency for Science, Technology and Research, Singapore
Grant:
National Science Scholarship (K.S.N.
More from this funder
Name:
Oxford-UCL Center for the Advancement of Sustainable Medical Innovation
Grant:
J.A.S.
D.A.B
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Name:
National Institutes of Health
Grant:
R01 grant HL095722 (J.M.K.
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Name:
Fundação para a Ciência e a Tecnologia
Grant:
MIT-PortugalTB/ECE/0013/2013 (J.M.K
Publisher:
Wiley
Journal:
Biotechnology and Bioengineering More from this journal
Volume:
116
Issue:
2
Pages:
307-319
Publication date:
2018-11-08
Acceptance date:
2018-08-06
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
Pmid:
30063243
Language:
English
Keywords:
Pubs id:
pubs:894179
UUID:
uuid:6b866490-0f2c-4bf6-bb36-ea1fc0b9b187
Local pid:
pubs:894179
Source identifiers:
894179
Deposit date:
2018-08-17

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