Journal article
Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.
- Abstract:
- The quinoline-5,8 dicarboxylic acid scaffold has been identified by fragment-based approach as new potential lead compound for the development of JMJD3 inhibitors. Among them, compound 3 shows low micromolar inhibitory activity against JMJD3. The experimental evaluation of inhibition activity vs. related seven isoforms of JMJD3 highlighted an unprecedented selectivity towards the biological target of interest.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Italian Association for Cancer Research
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Cariplo Foundation
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- ChemMedChem Journal website
- Volume:
- 13
- Issue:
- 12
- Pages:
- 1160-1164
- Publication date:
- 2018-04-06
- Acceptance date:
- 2018-04-03
- DOI:
- EISSN:
-
1860-7187
- ISSN:
-
1860-7179
- Pmid:
-
29633584
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:843562
- UUID:
-
uuid:6b7c0653-cada-4dff-9680-39e20b525b12
- Local pid:
- pubs:843562
- Deposit date:
- 2018-05-02
Terms of use
- Copyright holder:
- Oppermann et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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