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Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.

Abstract:
In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.
Publication status:
Published

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Publisher copy:
10.1038/354453a0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
Expand authors...
Journal:
Nature
Volume:
354
Issue:
6353
Pages:
453-459
Publication date:
1991-12-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
25268
Language:
English
Keywords:
Pubs id:
pubs:25268
UUID:
uuid:6b7afc95-e89a-4711-b12e-1c7f362bf2c8
Local pid:
pubs:25268
Deposit date:
2012-12-19

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