Journal article
Identification of small interfering RNA targeting Signal Transducer and Activator of Transcription 6: Characterisation and selection of candidates for pre-clinical development
- Abstract:
-
The interleukin (IL)-13 pathway and its associated transcription factor, signal transducer and activator of transcription 6 (STAT6), have been clearly implicated in the pathogenesis of bronchial asthma. We have developed a system to effectively screen the STAT6 gene for targeting with small interfering (si) RNA molecules. By incorporating an in silico and in vitro screening system we were able to identify fourteen siRNA molecules suitable for pre-clinical drug d...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Library Publishing Media Publisher's website
- Journal:
- Journal of RNAi and Gene Silencing Journal website
- Publication date:
- 2010-08-25
- Acceptance date:
- 2010-08-20
- ISSN:
-
1747-0854
Item Description
Terms of use
- Copyright holder:
- Healey et al
- Copyright date:
- 2010
- Notes:
- © The Authors: This is an open access article, published under the terms of the Creative Commons Attribution Non-Commercial License. This license permits noncommercial use, distribution and reproduction of the article, provided the original work is appropriately acknowledged with correct citation details.
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