Journal article icon

Journal article

Identification of small interfering RNA targeting Signal Transducer and Activator of Transcription 6: Characterisation and selection of candidates for pre-clinical development

Abstract:

The interleukin (IL)-13 pathway and its associated transcription factor, signal transducer and activator of transcription 6 (STAT6), have been clearly implicated in the pathogenesis of bronchial asthma. We have developed a system to effectively screen the STAT6 gene for targeting with small interfering (si) RNA molecules. By incorporating an in silico and in vitro screening system we were able to identify fourteen siRNA molecules suitable for pre-clinical drug d...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
Publisher:
Library Publishing Media
Journal:
Journal of RNAi and Gene Silencing More from this journal
Publication date:
2010-08-25
Acceptance date:
2010-08-20
ISSN:
1747-0854
Keywords:
Pubs id:
pubs:700316
UUID:
uuid:6b78f0ab-b01a-4fce-9ad6-f15e2a5e65d9
Local pid:
pubs:700316
Source identifiers:
700316
Deposit date:
2017-06-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP