Homocysteine modification of HLA antigens and its immunological consequences.

Journal article

Homocysteine-treated cells can be specifically lysed by cytotoxic T lymphocytes (CTL) identifiable in patients with ankylosing spondylitis and reactive arthritis. Sensitization of target cells involves disulfide bonding and the interaction between homocysteine and HLA antigens occurs in a pre-Golgi compartment in the cells. Salmonella-infected B cells are also lysed by homocysteine-specific CTL, suggesting that intracellular invading microorganisms may provide homocysteine which would gain ac...

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Authors: Gao, X; Wordsworth, P; Mcmichael, A; Kyaw, M; Seifert, M

• Publication status: Published
• Journal: European journal of immunology
• Volume: 26
• Issue: 7
• Pages: 1443-1450
• Publication date: 1996-07-01
• DOI: 10.1002/eji.1830260707
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Base Sequence; Lymphocyte Count; Cell Line; Middle Aged; Salmonella Infections; Humans; B-Lymphocytes; HLA Antigens; Male; Sulfhydryl Compounds; Female; Immunization; HLA-B27 Antigen; T-Lymphocytes, Cytotoxic; Endoplasmic Reticulum; Kinetics; Homocysteine; Adult; Epitopes; Molecular Sequence Data; Stem Cells