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Circulating B-cell activating factor level predicts clinical response of chronic graft-versus-host disease to extracorporeal photopheresis.

Abstract:

Extracorporeal photopheresis (ECP) is an important therapeutic option in steroid-refractory chronic graft-versus-host disease (cGVHD). Few biomarkers predicting response exist. We measured serum B-cell activating factor (BAFF) in 46 cGVHD patients receiving ECP before and during treatment course. BAFF level at 1 month of ECP predicted 3- and 6-month skin disease response, with BAFF less than 4 ng/mL associated with significant skin improvement and complete resolution in 11 of 20 patients. Hig...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
118
Issue:
24
Pages:
6446-6449
Publication date:
2011-12-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:227143
UUID:
uuid:6b720896-651f-4052-b45a-b641a7503148
Local pid:
pubs:227143
Source identifiers:
227143
Deposit date:
2012-12-19

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