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Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.

Abstract:

The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1) are not only expressed in thymocytes, but also in mature T cells. Our data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.176.3.1439

Authors


Willinger, T More by this author
Freeman, T More by this author
Herbert, M More by this author
Hasegawa, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
3
Pages:
1439-1446
Publication date:
2006-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:6b6dc6d7-d00f-404f-a97c-8dc8cfbc548d
Source identifiers:
33363
Local pid:
pubs:33363

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