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Mapping cis-and trans-regulatory effects across multiple tissues in twins

Abstract:

Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals. Here, we present a comprehensive analysis of gene expression across multiple tissues conducted in a large set of mono-and dizygotic twins that allows systematic dissection of genetic (cis and trans) and non-genetic effects on gene expression....

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Publisher copy:
10.1038/ng.2394

Authors


Journal:
Nature Genetics More from this journal
Volume:
44
Issue:
10
Pages:
1084-1089
Publication date:
2012-10-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Pubs id:
pubs:354618
UUID:
uuid:6b6d45dd-af9b-44bc-9c88-aed0d052cc4c
Local pid:
pubs:354618
Source identifiers:
354618
Deposit date:
2013-11-16

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