Journal article icon

Journal article

Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic.

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death. Despite improvements in the clinical management, the prognosis of PDAC remains dismal. In the present comprehensive review, we will examine the knowledge of PDAC genetics and the new insights into human genome sequencing and clonal evolution. Additionally, the biology and the role of the stroma in tumour progression and response to treatment will be presented. Furthermore, we will describe the evidence on tum...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1016/j.bbcan.2014.12.001

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst For Radiation Oncology
Role:
Author
Expand authors...
Kidani Memorial Trust More from this funder
Oxford Cancer Imaging Centre More from this funder
Oxford Cancer Research Centre More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biochimica et biophysica acta Journal website
Volume:
1855
Issue:
1
Pages:
61-82
Publication date:
2015-01-05
DOI:
EISSN:
1879-2561
ISSN:
0006-3002
URN:
uuid:6b6b8856-8a2d-4d5a-9851-273698fb2768
Source identifiers:
492616
Local pid:
pubs:492616

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP